CSF tests in the differential diagnosis of Creutzfeldt-Jakob disease

  title={CSF tests in the differential diagnosis of Creutzfeldt-Jakob disease},
  author={P. S{\'a}nchez-Juan and A. Green and A. Ladogana and N. Cuadrado-Corrales and R. S{\'a}anchez-Valle and E. Mitrováa and K. Stoeck and T. Sklaviadis and J. Kulczycki and K. Hess and M. Bodemer and D. Slivarichová and A. Saiz and M. Calero and L. Ingrosso and R. Knight and A. Janssens and C. V. van Duijn and I. Zerr},
  pages={637 - 643}
  • P. Sánchez-Juan, A. Green, +16 authors I. Zerr
  • Published 2006
  • Medicine
  • Neurology
  • Objectives: To analyze the diagnostic sensitivity and specificity of various brain-derived proteins (14-3-3, Tau, neuron specific enolase [NSE], and S100b) in the CSF of patients with Creutzfeldt-Jakob disease (CJD) and to analyze biologic factors that modify these parameters. Methods: CSF was tested for 14-3-3, Tau, NSE, and S100b in 1,859 patients with sporadic, genetic, iatrogenic, and variant CJD, and in 1,117 controls. Results: The highest sensitivity was achieved for 14-3-3 and Tau in… CONTINUE READING
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