CSF tests in the differential diagnosis of Creutzfeldt-Jakob disease

@article{SnchezJuan2006CSFTI,
  title={CSF tests in the differential diagnosis of Creutzfeldt-Jakob disease},
  author={P. S{\'a}nchez-Juan and A. Green and A. Ladogana and N. Cuadrado-Corrales and R. S{\'a}anchez-Valle and E. Mitrováa and K. Stoeck and T. Sklaviadis and J. Kulczycki and K. Hess and M. Bodemer and D. Slivarichov{\'a} and A. Saiz and M. Calero and L. Ingrosso and R. Knight and A. Janssens and C. V. van Duijn and I. Zerr},
  journal={Neurology},
  year={2006},
  volume={67},
  pages={637 - 643}
}
Objectives: To analyze the diagnostic sensitivity and specificity of various brain-derived proteins (14-3-3, Tau, neuron specific enolase [NSE], and S100b) in the CSF of patients with Creutzfeldt-Jakob disease (CJD) and to analyze biologic factors that modify these parameters. Methods: CSF was tested for 14-3-3, Tau, NSE, and S100b in 1,859 patients with sporadic, genetic, iatrogenic, and variant CJD, and in 1,117 controls. Results: The highest sensitivity was achieved for 14-3-3 and Tau in… Expand
Influence of timing on CSF tests value for Creutzfeldt-Jakob disease diagnosis
TLDR
Sensitivity and absolute levels of CJD markers increased with disease progression and were modulated by the codon 129 genotype, especially in young patients or those who are MV atcodon 129. Expand
The diagnostic efficiency of biomarkers in sporadic Creutzfeldt-Jakob disease compared to Alzheimer's disease
TLDR
It is concluded that the combination of more than one CSF marker for neurodegeneration can improve the diagnostic test accuracy for sCJD against neurological controls including patients with other dementias. Expand
Tau and 14-3-3 of genetic and sporadic Creutzfeldt–Jakob disease patients in Israel
TLDR
It is concluded that CSF biomarkers, Tau and 14-3-3, may be used in the diagnosis in both patients’ populations, presenting a similar sensitivity yet Tau assay having higher specificity. Expand
CSF Tau proteins reduce misdiagnosis of sporadic Creutzfeldt–Jakob disease suspected cases with inconclusive 14-3-3 result
TLDR
It is suggested that t-Tau protein assay is of significant importance as a second marker in identifying 14-3-3 false-positive results among sCJD probable cases. Expand
A comparison of tau and 14-3-3 protein in the diagnosis of Creutzfeldt-Jakob disease
TLDR
In this study, tau is superior to 14-3-3 protein as a marker in the diagnosis of Creutzfeldt-Jakob disease, and is as efficient singly compared to a variety of combinations with 14- 3-3protein. Expand
Diagnostic accuracy of cerebrospinal fluid protein markers for sporadic Creutzfeldt-Jakob disease in Canada: a 6-year prospective study
TLDR
CSF 14-3-3, tau and S100B proteins are useful diagnostic markers of sCJD even in a low-prevalence clinical population, and CSF tau showed better overall diagnostic accuracy than 14- 3-3 or S 100B. Expand
Diagnostic value of CSF protein profile in a Portuguese population of sCJD patients
TLDR
Both 14-3-3, t-tau and S-100b are sensitive markers for sCJD, but 14-2-3 specificity seems to be lower in this special clinical setting of rapidly progressing dementias, and it is proposed that in cases with a 14- 3-3 weak positive result, or in young patients with long disease duration, a second CSF marker would be valuable for the diagnosis. Expand
Cerebrospinal fluid markers in Creutzfeldt-Jakob disease
TLDR
The results suggest that 14-3-3 protein may be the better marker for CJD, tT Tau/P-Tau ratio and tTau are also efficient markers, but showed slightly inferior diagnostic properties in this study. Expand
Cerebrospinal Fluid Markers in Sporadic Creutzfeldt-Jakob Disease
TLDR
While the 14-3-3 assay and tau protein levels were the most sensitive indicators of sCJD, the highest sensitivity, specificity and positive predictive value were obtained when all the above markers were combined. Expand
Subtype Specific CSF Biomarkers in Sporadic Creutzfeldt-Jakob Disease
TLDR
The detection of pre-mortem distinction targets might be useful diagnostic tool for sCJD in subtype specific manner and might lead towards differential treatment approaches. Expand
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References

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A prospective study of CSF markers in 250 patients with possible Creutzfeldt–Jakob disease
TLDR
Both 14-3-3 and tau protein are sensitive and specific biomarkers for CJD, but the phase of the disease in which the CSF sample was obtained should be taken into account. Expand
Tau protein and 14-3-3 protein in the differential diagnosis of Creutzfeldt–Jakob disease
TLDR
The differential diagnostic significance of the 14-3-3 immunoblot is similar to that of the tau-protein ELISA, and for patients with type II prion protein and methionine/valine or valine/Valine polymorphism at codon 129, t Tau-protein has a higher diagnostic sensitivity than 14- 3-3 protein. Expand
Sensitivity of 14-3-3 protein test varies in subtypes of sporadic Creutzfeldt-Jakob disease
TLDR
The Creutzfeldt-Jakob disease clinical subtype should be considered when interpreting results of the 14-3-3 test, as it appears to be related to the PrPSc type and not to the codon 129 genotype. Expand
14-3-3 Protein, Neuron-Specific Enolase, and S-100 Protein in Cerebrospinal Fluid of Patients with Creutzfeldt-Jakob Disease
  • P. Beaudry, P. Cohen, +5 authors & on Behalf of the French Research Group on Epidemio
  • Biology, Medicine
  • Dementia and Geriatric Cognitive Disorders
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TLDR
It appears that there is no additional advantage at the moment to include NSE and/or S-100 protein in the exploration of clinically suspected CJD cases, and the CSF 14-3-3 protein test alone has the highest specificity and good sensitivity. Expand
Use of 14–3–3 and other brain-specific proteins in CSF in the diagnosis of variant Creutzfeldt-Jakob disease
TLDR
CSF protein 14–3–3 is not as useful a marker for vCJD as it is for sporadic CJD but as concentrations may be increased in many forms of non-CJD dementia, this may limit its usefulness as a diagnostic test. Expand
Decreased Levels of Amyloid-beta 1-42 in Cerebrospinal Fluid of Creutzfeldt-Jakob Disease Patients.
TLDR
It is concluded that determination of Abeta_1-42 levels in CSF can be useful for identifying false positive 14-3-3 results in suspected CJD patients. Expand
Current clinical diagnosis in Creutzfeldt‐Jakob disease: Identification of uncommon variants
TLDR
The widening spectrum of diagnostic techniques in CJD is not only useful in the increased accuracy of the clinical diagnosis but should also lead to the identification of more atypical cases of sporadic CJD. Expand
Challenging the clinical utility of the 14-3-3 protein for the diagnosis of sporadic Creutzfeldt-Jakob disease.
TLDR
Testing for the 14-3-3 protein in cerebrospinal fluid is only modestly sensitive to sporadic CJD, and it is cautioned against ruling out a diagnosis of the disease on the basis of a negative 14- 3-3 result. Expand
Analysis of EEG and CSF 14-3-3 proteins as aids to the diagnosis of Creutzfeldt–Jakob disease
Objective: To improve diagnostic criteria for sporadic Creutzfeldt–Jakob disease (CJD). Methods: Pooled data on initial and final diagnostic classification of suspected CJD patients were accumulated,Expand
Elevation of neuron‐specific enolase in serum and cerebrospinal fluid of early stage Creutzfeldt–Jakob disease
TLDR
The results suggest that the mechanism of elevation of serum NSE may not be a simple leakage from CSF, and that the measurement of serumNSE level may be useful for diagnosis of early stage CJD. Expand
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