CSF tau protein phosphorylated at threonine 231 correlates with cognitive decline in MCI subjects.

Abstract

In this longitudinal study of 77 patients with mild cognitive impairment (MCI), the authors analyzed whether levels of tau protein phosphorylated at threonine 231 (p-tau(231)) in CSF correlate with progression of cognitive decline. High CSF p-tau(231) levels at baseline, but not total tau protein levels, correlated with cognitive decline and conversion from MCI to AD. Independently, old age and APOE-epsilon 4 carrier status were predictive as well. Our data indicate that an increased p-tau(231) level is a potential risk factor for cognitive decline in patients with MCI.

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@article{Buerger2002CSFTP, title={CSF tau protein phosphorylated at threonine 231 correlates with cognitive decline in MCI subjects.}, author={K. Buerger and Stefan J. Teipel and Raymond P. Zinkowski and Kay Blennow and Hajime Arai and R. R. Engel and Klaus F Hofmann-Kiefer and Cheryl McCulloch and Ursula Ptok and Reinhard Heun and Niels Andreasen and J F Debernardis and Daniel Kerkman and H- J Moeller and Peter Francis Davies and Harald Hampel}, journal={Neurology}, year={2002}, volume={59 4}, pages={627-9} }