CSF soluble amyloid precursor proteins in the diagnosis of incipient Alzheimer disease.

@article{Perneczky2011CSFSA,
  title={CSF soluble amyloid precursor proteins in the diagnosis of incipient Alzheimer disease.},
  author={Robert Perneczky and Amalia Tsolakidou and Andreas Arnold and Janine Diehl-Schmid and Timo Grimmer and Hans F{\"o}rstl and Alexander Kurz and Panagiotis Alexopoulos},
  journal={Neurology},
  year={2011},
  volume={77 1},
  pages={35-8}
}
OBJECTIVE To explore if soluble amyloid precursor proteins (sAPP) in CSF improve the identification of patients with incipient Alzheimer disease (AD) in a group of patients with mild cognitive impairment (MCI). METHODS A cohort study with follow-up assessments of 58 patients with MCI with baseline CSF sampling was conducted: 21 patients had progressed to probable AD (MCI-AD), 27 still had MCI, 8 had reverted to normal (MCI-NAD), and 2 patients with frontotemporal dementia (FTD) were excluded… CONTINUE READING

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