CSF phosporylated TAU protein levels correlate with cerebral glucose metabolism assessed with PET in Alzheimer's disease.

@article{Ceravolo2008CSFPT,
  title={CSF phosporylated TAU protein levels correlate with cerebral glucose metabolism assessed with PET in Alzheimer's disease.},
  author={R Ceravolo and D. Borghetti and Lorenzo Kiferle and Gloria Tognoni and Assuero Giorgetti and Danilo Neglia and Nadia Sassi and Daniela Frosini and Concetta Rossi and Lucia Petrozzi and Gabriele Siciliano and L. Murri},
  journal={Brain research bulletin},
  year={2008},
  volume={76 1-2},
  pages={80-4}
}
One major goal of drug development would be the establishment of biomarkers as objective indicators of normal biological and pathogenetic processes, or pharmacological response to a therapeutic intervention. A potential approach is to investigate proteins in CSF linked to key neuropathological features of Alzheimer's disease (AD). Recently CSF phosphorylated-Tau (p-Tau) levels have been reported to reflect neurofibrillary changes within the brain of patients with AD, however the use of serial… CONTINUE READING

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