CSF monoamine metabolites and lethality of suicide attempts in depressed patients with alcohol dependence.

@article{Sher2007CSFMM,
  title={CSF monoamine metabolites and lethality of suicide attempts in depressed patients with alcohol dependence.},
  author={L Sher and Maria A. Oquendo and Michael F Grunebaum and Ainsley Keller Burke and Yung-yu Huang and J. John Mann},
  journal={European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology},
  year={2007},
  volume={17 1},
  pages={12-5}
}
BACKGROUND Alcohol dependence (alcoholism) and major depressive disorder are frequently comorbid and are risk factors for suicidal behavior. Monoaminergic abnormalities have been implicated in the pathophysiology of depression, alcohol dependence, and suicidal behavior. Lower cerebrospinal fluid (CSF) 5-hydroxyindolacetic acid (5-HIAA) levels are associated with higher lethality of suicide attempts in major depression and predict a higher rate of future suicide. We sought to study the… CONTINUE READING