CSF iron, ferritin and transferrin levels in restless legs syndrome

@article{Mizuno2005CSFIF,
  title={CSF iron, ferritin and transferrin levels in restless legs syndrome},
  author={Soichi Mizuno and Takumi Mihara and Tsuyoshi Miyaoka and Takuzi Inagaki and Jun Horiguchi},
  journal={Journal of Sleep Research},
  year={2005},
  volume={14}
}
The aim of this study is evaluating iron, ferritin, and transferrin in both serum and CSF in patients of restless legs syndrome (RLS), based on the hypothesis that iron deficiency in the central nervous system (CNS) causes the symptoms as a result of the dysfunction of dopaminergic systems. These parameters, polysomnographic sleep measures, and subjective evaluation of the sleep quality were compared in 10 patients of idiopathic RLS (RLS group) and 10 age‐matched patients of psychophysiological… 
Ferritin subunits in CSF are decreased in restless legs syndrome.
TLDR
The results establish a protein standard in RLS, provide a comparative analysis of protein-controlled versus volumetric immunoblot techniques, and argue for a profound loss of iron storage capacity in the brain inRLS, specifically in the early onset RLS phenotype.
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TLDR
Iron deficiency induced by its metabolism dysfunctions in peripheral and central systems might cause PD-RLS through decreasing brain DA and 5-HT.
Altered iron metabolism in lymphocytes from subjects with restless legs syndrome.
TLDR
The findings indicate a balance between input and output with no net iron change but probable overall increase in iron turnover, and that iron management proteins from lymphocytes are at a minimum an alternative and independent marker of cellular iron metabolism.
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TLDR
Findings from this study show that iron supplementation for persons with RLS not only improves motor and sensory symptoms but might also improve sleep, sleepiness, depression, fatigue, and QoL and should be considered by health care providers for treatment of RLS.
BRAIN IRON DEFICIENCY IN HUMANS AND ANIMAL MODELS
TLDR
The results establish a protein standard in RLS, provide a comparative analysis of protein-controlled vs. volumetric immunoblot techniques, and argue for a profound loss of iron storage capacity in the brain in R LS, specifically in the early-onset RLS phenotype.
Restless legs syndrome: pathophysiology and the role of iron and folate.
  • L. Patrick
  • Medicine
    Alternative medicine review : a journal of clinical therapeutic
  • 2007
TLDR
Pregnant women, patients with end-stage renal disease or iron-deficiency anemia, and children with attention deficit hyperactivity disorder (AD/HD) have a significantly higher prevalence of RLS.
Prevalence and characteristics of restless legs syndrome (RLS) in the elderly and the relation of serum ferritin levels with disease severity: hospital-based study from Istanbul, Turkey.
TLDR
The data show that RLS is very common in the elderly and the disease is more severe in patients with lower ferritin levels, compared to those of mild-moderate disease group, p<0.001.
Efficacy of Intravenous Iron Sucrose in Hemodialysis Patients with Restless Legs Syndrome (RLS): A Randomized, Placebo-Controlled Study
TLDR
I iron sucrose is a safe and effective treatment for reducing RLS symptoms in HD patients over the short-term, and there were no significant differences between IV-iron and placebo groups in Cr, urea, iPTH, and Kt/V.
The role of iron in restless legs syndrome
  • R. Allen, C. Earley
  • Psychology, Medicine
    Movement disorders : official journal of the Movement Disorder Society
  • 2007
TLDR
The data are presented documenting that both peripheral and CNS iron insufficiency occur with RLS symptoms, and postulates combining dopaminergic and iron causes of RLS are presented.
Association between low serum ferritin and restless legs syndrome in patients with attention deficit hyperactivity disorder.
TLDR
It was showed that depleted iron stores might increase the risk of having RLS in ADHD subjects and iron deficiency, which is associated with both ADHD and RLS seems to be an important modifying factor in the relationship between these two conditions.
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