CSF hypocretin-1 levels in restless legs syndrome.

@article{StiasnyKolster2003CSFHL,
  title={CSF hypocretin-1 levels in restless legs syndrome.},
  author={Karin Stiasny-Kolster and Emmanuel Mignot and Liu Ling and Jens Carsten M{\"o}ller and W. Cassel and Wolfgang Hermann Oertel},
  journal={Neurology},
  year={2003},
  volume={61 10},
  pages={
          1426-9
        }
}
CSF hypocretin-1 levels at 6 PM did not significantly differ between patients with restless legs syndrome (RLS) and control subjects as measured by direct radioimmunoassay and after acid extraction. The authors did not observe significant differences between early onset and late onset RLS. Hypocretin-1 levels did not correlate with RLS severity or polysomnographic measures. These results contrast with previous findings reporting significantly increased CSF hypocretin-1 in the late evening and… CONTINUE READING

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