CSF findings in 250 patients with serologically confirmed West Nile virus meningitis and encephalitis

@article{Tyler2006CSFFI,
  title={CSF findings in 250 patients with serologically confirmed West Nile virus meningitis and encephalitis},
  author={Kenneth L. Tyler and John Pape and Robin J. Goody and Mary Corkill and Bette K Kleinschmidt-DeMasters},
  journal={Neurology},
  year={2006},
  volume={66},
  pages={361 - 365}
}
Objective: To provide a large, comprehensive evaluation of the CSF findings in patients with serologically confirmed West Nile virus (WNV), CNS disease, and their correlation with outcome. Methods: CSF samples from 334 WNV-infected hospitalized patients were analyzed. Information was available and extracted from the medical records of 250 of these patients, and CSF parameters correlated with clinical and epidemiologic features of disease (e.g., patient age, sex, outcome). Results: Patients with… 

Tables from this paper

Emergence of human West Nile Virus infection in Sri Lanka

This is the first report of human WNV infection identified in patients presenting with encephalitis or meningoencephalitis in Sri Lanka, and there were no clinical, routine laboratory or radiological features that were distinguishable from other infectious causes of meningitis.

The Importance of Haematological and Biochemical Findings in Patients with West Nile Virus Neuroinvasive Disease

Prolonged neutrophilic predominance in CSF can occasionally be present, as well as hypoglycorrhachia, and patients with encephalitis, high serum CRP and high CSF protein level have a higher risk of fatal outcome.

West Nile virus neuroinvasive disease

Recent studies suggest that some WNV‐infected patients have persistent WNV IgM serum and/or cerebrospinal fluid antibody responses, and this may require revision of current serodiagnostic criteria.

A brief report of West Nile Virus neuroinvasive disease in the summer of 2012 in Hamilton, Ontario.

  • L. JiaoC. Main
  • Medicine
    The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale
  • 2014
West Nile neuroinvasive disease is a severe infectious disease that is associated with a high mortality rate, especially in immunocompromised hosts. Physicians who are aware of its clinical

Hospital-based enhanced surveillance for West Nile virus neuroinvasive disease

Assessment of laboratory testing of patients with suspected viral meningitis or encephalitis at selected hospitals serving WNV-endemic regions in three states indicates that over a third of WNV infections in patients with clinically compatible neurological illness might be undiagnosed due to either lack of testing or inappropriate testing, leading to substantial underestimates of W NV neuroinvasive disease burden.

Three case reports of West Nile virus neuroinvasive disease: lessons from real-life clinical practice

It is underlined that West Nile neuroinvasive disease should always be included in the differential diagnosis of meningoencephalitis during WNV transmission period.

Characterisation of the cerebrospinal fluid of horses with West Nile virus neuroinvasive disease.

The CSF findings of WNV encephalomyelitis patients are non-specific and variable but facilitate the differential diagnosis, and neutrophilic than mononuclear pleocytosis was identified with WNV infection.

West Nile Virus Infection in the Immunocompromised Patient

  • M. Levi
  • Medicine
    Current Infectious Disease Reports
  • 2013
With significant morbidity associated with donor transmission, specific pretransplant screening recommendations are reviewed and recipients of solid organ transplants are studied.

West Nile virus encephalitis in kidney transplanted patient, first case in Hungary : Case report

The authors present the first transplanted Hungarian patient with WNV encephalitis, who was hospitalized with epigastric pain, diarrhea, continuous fever, and decreasing amount of urine, and WNV infection was confirmed by serological examinations.

West Nile Virus Neuroinvasive Disease

West Nile virus (WNV) infection now represents one of the most common arboviral diseases worldwide and Physicians should maintain a high degree of clinical suspicion for WNV infections in patients presenting with an acute febrile illness, especially those with central nervous system manifestations in summer and fall.
...

References

SHOWING 1-10 OF 16 REFERENCES

West Nile virus infection

An overlapping spectrum of meningitis, encephalitis, and myeloradiculitis occurs in CNS WNV infection, and fever, rash, abdominal and back pain, preceding a proximal, asymmetric flaccid weakness, with CSF pleocytosis help distinguish the motor syndrome from Guillain–Barré syndrome.

The outbreak of West Nile virus infection in the New York City area in 1999.

BACKGROUND In late August 1999, an unusual cluster of cases of meningoencephalitis associated with muscle weakness was reported to the New York City Department of Health. The initial epidemiologic

Neurologic Manifestations and Outcome of West Nile Virus Infection

Movement disorders, including tremor, myoclonus, and parkinsonism, may be present during acute illness with WNV infection, although an irreversible poliomyelitis-like syndrome may result.

Neurologic manifestations and outcome of West Nile virus infection.

Movement disorders, including tremor, myoclonus, and parkinsonism, may be present during acute illness with WNV infection, although an irreversible poliomyelitis-like syndrome may result.

Naturally acquired West Nile virus encephalomyelitis in transplant recipients: clinical, laboratory, diagnostic, and neuropathological features.

Naturally acquired WNV encephalitis in transplant recipients shows diagnostic, clinical, and laboratory features similar to those reported in nonimmunocompromised individuals, but neuroimaging, electroencephalography, and autopsy results verify that these patients develop neurological damage at the severe end of the spectrum.

Clinical findings of West Nile virus infection in hospitalized patients, New York and New Jersey, 2000.

Clinicians in the Northeast should maintain a high level of suspicion during the summer when evaluating older patients with febrile illnesses and neurologic symptoms, especially if associated with gastrointestinal complaints or muscle weakness.

Herpes simplex encephalitis. Clinical Assessment.

Clinical data from 113 patients in whom the diagnosis was proved by viral isolation of herpes simplex encephalitis shows that diagnosis can be confirmed only by brain biopsy.

Cerebrospinal fluid findings in aseptic versus bacterial meningitis.

The majority of children with aseptic meningitis have a PMN predominance in the CSF, and the PMN majority is not limited to the first 24 hours of illness.

West Nile Virus–associated Flaccid Paralysis

A poliomyelitislike syndrome likely involving spinal anterior horn cells is the most common mechanism of WNV-associated paralysis and is associated with significant short- and long-term illness and death.

Use of Immunoglobulin M Cross-Reactions in Differential Diagnosis of Human Flaviviral Encephalitis Infections in the United States

Not surprisingly, similar virus specificity was observed with WN virus-elicited IgM in cerebrospinal fluid, and a subset of these specimens was even less reactive in the MAC-ELISA with dengue virus, a member of a different flavivirus serocomplex.