CSF Cation Changes following Subarachnoid Injection of Iohexol and Metrizamide in Rabbits

  title={CSF Cation Changes following Subarachnoid Injection of Iohexol and Metrizamide in Rabbits},
  author={Petr Mal{\'y} and G{\"o}ran A. Fex},
  journal={Acta Radiologica},
  pages={65 - 71}
  • P. Malý, G. Fex
  • Published 1 January 1984
  • Chemistry, Medicine
  • Acta Radiologica
Forty anaesthetized rabbits were injected subarachnoidally with equimolal doses, 0.48 mmol/kg body weight (= 185 mg I/kg), of iohexol and metrizamide, administered in solutions iso- and hyperosmolal to the CSF. Concentrations of Na, K, Ca and Mg in the CSF were determined before and 3 hours after the contrast medium injections. Iso-osmolal iohexol caused a uniform decrease in all four cations, which was believed to be a simple dilution. The hyperosmolal solution of iohexol caused a significant… 
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