CSF Aβ(42) and tau in Parkinson's disease with cognitive impairment.

  title={CSF Aβ(42) and tau in Parkinson's disease with cognitive impairment.},
  author={Thomas J. Montine and Min Shi and Joseph F Quinn and E. R. Peskind and Suzanne Craft and Carmen Ginghina and Kathryn A. Chung and Hojoong Kim and Douglas R. Galasko and Joseph Jankovic and Cyrus P Zabetian and James Ba Leverenz and Jing Zhang},
  journal={Movement disorders : official journal of the Movement Disorder Society},
  volume={25 15},
We tested the hypothesis that the CSF biomarker signature associated with Alzheimer's disease (AD) is present in a subset of individuals with Parkinson's disease and Dementia (PD-D) or with PD and Cognitive Impairment, Not Dementia (PD-CIND). We quantified CSF Aβ(42), total tau (T-tau), and phospho-tau (P181-tau) using commercially available kits. Samples were from 345 individuals in seven groups (n): Controls ≤50 years (35), Controls >50 years (115), amnestic Mild Cognitive Impairment (aMCI… CONTINUE READING

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