CSF-1-dependant donor-derived macrophages mediate chronic graft-versus-host disease.

  title={CSF-1-dependant donor-derived macrophages mediate chronic graft-versus-host disease.},
  author={Kylie Anne Alexander and Ryan Flynn and Katie E Lineburg and Rachel D Kuns and Bianca E. Teal and Stuart D. Olver and Mary Lor and Neil C. Raffelt and Motoko Koyama and Lucie Leveque and Laetitia Le Texier and Michelle Melino and Kate A Markey and Antiopi Varelias and Christian R Engwerda and Jonathan S. Serody and Baptiste Janela and Florent Ginhoux and Andrew D Clouston and Bruce R Blazar and Geoffrey R Hill and Kelli P A MacDonald},
  journal={The Journal of clinical investigation},
  volume={124 10},
Chronic GVHD (cGVHD) is the major cause of late, nonrelapse death following stem cell transplantation and characteristically develops in organs such as skin and lung. Here, we used multiple murine models of cGVHD to investigate the contribution of macrophage populations in the development of cGVHD. Using an established IL-17-dependent sclerodermatous cGVHD model, we confirmed that macrophages infiltrating the skin are derived from donor bone marrow (F4/80+CSF-1R+CD206+iNOS-). Cutaneous cGVHD… CONTINUE READING