CSF-1 blockade impairs breast cancer osteoclastogenic potential in co-culture systems.

  title={CSF-1 blockade impairs breast cancer osteoclastogenic potential in co-culture systems.},
  author={Chiara Liverani and Laura Mercatali and Chiara Spadazzi and Federico La Manna and Alessandro De Vita and Nada Riva and Sebastiano Calpona and Marianna Ricci and Alberto Bongiovanni and Erica Gunelli and Michele Zanoni and Francesco Fabbri and Wainer Zoli and Dino Amadori and Toni Ibrahim},
Metastatic bone disease has a major impact on the morbidity and mortality of breast cancer patients, and studies on bone metastasis biology have led to the development of the most widely used drugs for bone metastases treatment: zoledronate (Zol) and denosumab (Den). The aim of the present study was to assess the effect of soluble mediators produced by breast cancer cells on human osteoclast maturation in a co-culture model. We also tested the ability of zoledronate, denosumab and 5H4, an… CONTINUE READING
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