CSF-1 and cell cycle control in macrophages.

  title={CSF-1 and cell cycle control in macrophages.},
  author={John A Hamilton},
  journal={Molecular reproduction and development},
  volume={46 1},
Control of cell proliferation involves a finely interwoven network of positive and negative cell cycle regulators. Signal transduction pathways linking c-fms (CSF-1R) to cellular proliferation and differentiation are being explored. Part of the strategy is to use a series of G1 inhibitors to help pinpoint relevant targets. Several inhibitors-8Br-cAMP, interferon gamma (IFN gamma), INF alpha/beta, lipopolysaccharide (LPS), tumor necrosis factor-alpha (TNF alpha), and dimethylamiloride-suppress… CONTINUE READING