CSE1L Links cAMP/PKA and Ras/ERK pathways and regulates the expressions and phosphorylations of ERK1/2, CREB, and MITF in melanoma cells.

@article{Lee2016CSE1LLC,
  title={CSE1L Links cAMP/PKA and Ras/ERK pathways and regulates the expressions and phosphorylations of ERK1/2, CREB, and MITF in melanoma cells.},
  author={W R Lee and S W Shen and Pei-Ru Wu and C L Chou and Yi-Hsien Shih and Chung-Min Yeh and K T Yeh and M C Jiang},
  journal={Molecular carcinogenesis},
  year={2016},
  volume={55 11},
  pages={1542-1552}
}
The Ras/ERK (extracellular signal-regulated protein kinase) and cAMP/PKA (protein kinase A) pathways are essential for the transcriptional activities of CREB (cAMP response element binding protein) and MITF (microphthalmia-associated transcription factor) in melanogenesis and the progression of melanoma. However, the interaction between Ras/ERK and cAMP/PKA… CONTINUE READING