CSD, BBB and MMP-9 elevations: animal experiments versus clinical phenomena in migraine.

@article{Gupta2009CSDBA,
  title={CSD, BBB and MMP-9 elevations: animal experiments versus clinical phenomena in migraine.},
  author={Vinod Kumar Gupta},
  journal={Expert review of neurotherapeutics},
  year={2009},
  volume={9 11},
  pages={1595-614}
}
Cortical spreading depression (CSD) has been at the center stage of migraine pathophysiology for approximately six decades. Reanalysis of CSD reveals several major unbridgeable gaps in this experimental neurophysiologic concept for migraine. Key phenotypic and pharmacological features of migraine challenge the assumed pathophysiologic role of CSD. Detection of subclinical infarct-like white matter lesions (WMLs) in the brain of some migraine patients stimulated the concept of CSD-related BBB… CONTINUE READING