CSB interacts with SNM1A and promotes DNA interstrand crosslink processing

  title={CSB interacts with SNM1A and promotes DNA interstrand crosslink processing},
  author={Teruaki Iyama and Sook Yan Lee and Brian R Berquist and Opher Gileadi and Vilhelm A. Bohr and Michael M. Seidman and Peter J McHugh and David M Wilson},
  booktitle={Nucleic acids research},
Cockayne syndrome (CS) is a premature aging disorder characterized by photosensitivity, impaired development and multisystem progressive degeneration, and consists of two strict complementation groups, A and B. Using a yeast two-hybrid approach, we identified the 5'-3' exonuclease SNM1A as one of four strong interacting partners of CSB. This direct interaction was confirmed using purified recombinant proteins-with CSB able to modulate the exonuclease activity of SNM1A on oligonucleotide… CONTINUE READING
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