CSAHi study: Evaluation of multi-electrode array in combination with human iPS cell-derived cardiomyocytes to predict drug-induced QT prolongation and arrhythmia--effects of 7 reference compounds at 10 facilities.

@article{Kitaguchi2016CSAHiSE,
  title={CSAHi study: Evaluation of multi-electrode array in combination with human iPS cell-derived cardiomyocytes to predict drug-induced QT prolongation and arrhythmia--effects of 7 reference compounds at 10 facilities.},
  author={Takashi Kitaguchi and Yuta Moriyama and Tomohiko Taniguchi and Atsuko Ojima and Hiroyuki Ando and Takaaki Uda and Koji Otabe and Masao Oguchi and Shigekazu Shimizu and Hiroyuki Saito and Maya Morita and Atsushi Toratani and Mahoko Asayama and Wataru Yamamoto and Emi Matsumoto and Daisuke Saji and Hiroki Ohnaka and Kohji Tanaka and Ikumi Washio and Nagahiro Miyamoto},
  journal={Journal of pharmacological and toxicological methods},
  year={2016},
  volume={78},
  pages={93-102}
}
INTRODUCTION Drug-induced QT prolongation is a major safety issue during drug development because it may lead to lethal ventricular arrhythmias. In this study, we evaluated the utility of multi-electrode arrays (MEA) with human induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs) to predict drug-induced QT prolongation and arrhythmia. METHODS… CONTINUE READING