CRY2 Is Associated with Depression

  title={CRY2 Is Associated with Depression},
  author={Catharina Lavebratt and Louise K. Sj{\"o}holm and Pia Soronen and Tiina Paunio and Marquis P. Vawter and William E. Bunney and Rolf Adolfsson and Yvonne Forsell and Joseph C Wu and John Kelsoe and Timo Partonen and Martin Schalling},
  booktitle={PloS one},
BACKGROUND Abnormalities in the circadian clockwork often characterize patients with major depressive and bipolar disorders. Circadian clock genes are targets of interest in these patients. CRY2 is a circadian gene that participates in regulation of the evening oscillator. This is of interest in mood disorders where a lack of switch from evening to morning oscillators has been postulated. PRINCIPAL FINDINGS We observed a marked diurnal variation in human CRY2 mRNA levels from peripheral blood… CONTINUE READING
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