CRY, a Drosophila Clock and Light-Regulated Cryptochrome, Is a Major Contributor to Circadian Rhythm Resetting and Photosensitivity

@article{Emery1998CRYAD,
  title={CRY, a Drosophila Clock and Light-Regulated Cryptochrome, Is a Major Contributor to Circadian Rhythm Resetting and Photosensitivity},
  author={Patrick Emery and W V So and Maki Kaneko and Jeffrey C. Hall and Michael Rosbash},
  journal={Cell},
  year={1998},
  volume={95},
  pages={669-679}
}
Light is a major environmental signal for circadian rhythms. We have identified and analyzed cry, a novel Drosophila cryptochrome gene. All characterized family members are directly photosensitive and include plant blue light photoreceptors. We show that cry transcription is under circadian regulation, influenced by the Drosophila clock genes period, timeless, Clock, and cycle. We also show that cry protein levels are dramatically affected by light exposure. Importantly, circadian… Expand

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A Constant Light-Genetic Screen Identifies KISMET as a Regulator of Circadian Photoresponses
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It is concluded that KIS is a key transcriptional regulator of genes that function in the CRY signaling cascade, and thus it plays an important role in the synchronization of circadian rhythms with the day∶night cycle. Expand
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The data presented in this thesis support the existence of a novel circadian photoreceptor and--pigment and set the stage for analysis of the signaling pathways involved in the CRY:TIM pathway. Expand
The Blue-Light Photoreceptor CRYPTOCHROME Is Expressed in a Subset of Circadian Oscillator Neurons in the Drosophila CNS
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Although CRY is absent in DN2s and DN3s, cry promoter activity and/or cry mRNA accumulation can be detected in these neurons, suggesting that CRY levels are regulated posttranscriptionally. Expand
Drosophila cryb mutation reveals two circadian clocks that drive locomotor rhythm and have different responsiveness to light.
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Light-Dependent Interactions between the Drosophila Circadian Clock Factors Cryptochrome, Jetlag, and Timeless
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It is shown that the affinity of Tim for Cry and Jetlag determines the sequential order of Tim and Cry degradation and thus reveals an intimate connection between the light-dependent degradation of these two proteins by the same proteasomal pathway. Expand
Belle and Aurora A are novel components of the circadian machinery in Drosophila melanogaster
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The cryb Mutation Identifies Cryptochrome as a Circadian Photoreceptor in Drosophila
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Cryb flies are rhythmic in constant darkness, correlating with robust PER and TIM cycling in certain pacemaker neurons, and is an apparent null mutation in a gene encoding Drosophila's version of the blue light receptor cryptochrome. Expand
Light-Induced Resetting of a Mammalian Circadian Clock Is Associated with Rapid Induction of the mPer1 Transcript
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TLDR
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TLDR
The cyclic expression of TIM protein in adult heads is shown and it lags behind peak levels of TIM RNA by several hours, suggesting that TIM mediates light-induced resetting of the circadian clock. Expand
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