CRUMBS is involved in the control of apical protein targeting during Drosophila epithelial development.

@article{Wodarz1993CRUMBSII,
  title={CRUMBS is involved in the control of apical protein targeting during Drosophila epithelial development.},
  author={Andreas Wodarz and Ferdi Grawe and Elisabeth Knust},
  journal={Mechanisms of development},
  year={1993},
  volume={44 2-3},
  pages={175-87}
}
The gene crumbs (crb) of Drosophila encodes a transmembrane protein with 30 EGF-like and four laminin A G-domain-like repeats in its extracellular domain. Loss-of-function mutations lead to severe disorganization and degeneration of ectodermally derived embryonic epithelia. In embryos homozygous for crb8F105, an amorphic allele, the CRUMBS protein is diffusely distributed in the cytoplasm instead of being apically localized as in wild-type; this mislocation occurs before any morphologically… CONTINUE READING

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