CRTAP Is Required for Prolyl 3- Hydroxylation and Mutations Cause Recessive Osteogenesis Imperfecta

@article{Morello2006CRTAPIR,
  title={CRTAP Is Required for Prolyl 3- Hydroxylation and Mutations Cause Recessive Osteogenesis Imperfecta},
  author={Roy Morello and Terry K. Bertin and Yuqing Chen and John H. Hicks and Laura Tonachini and Massimiliano Monticone and Patrizio Castagnola and Frank Rauch and Francis H Glorieux and Janice A. Vranka and Hans Peter B{\"a}chinger and James M. Pace and Ulrike Schwarze and Peter H Byers and Maryann Weis and Russell J. Fernandes and David R. Eyre and Zhenqiang Yao and Brendan F. Boyce and Brendan Lee},
  journal={Cell},
  year={2006},
  volume={127},
  pages={291-304}
}
Prolyl hydroxylation is a critical posttranslational modification that affects structure, function, and turnover of target proteins. Prolyl 3-hydroxylation occurs at only one position in the triple-helical domain of fibrillar collagen chains, and its biological significance is unknown. CRTAP shares homology with a family of putative prolyl 3-hydroxylases… CONTINUE READING