CRP promotes monocyte-endothelial cell adhesion via Fcgamma receptors in human aortic endothelial cells under static and shear flow conditions.

@article{Devaraj2006CRPPM,
  title={CRP promotes monocyte-endothelial cell adhesion via Fcgamma receptors in human aortic endothelial cells under static and shear flow conditions.},
  author={Sridevi Devaraj and Benjamin Davis and Scott I Simon and Ishwarlal Jialal},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2006},
  volume={291 3},
  pages={
          H1170-6
        }
}
Monocyte-endothelial cell adhesion is a key early event in atherogenesis. C-reactive protein (CRP), a cardiovascular risk marker, is known to stimulate ICAM and VCAM in human aortic endothelial cells (HAEC) and induces monocyte-endothelial cell adhesion. In this study, we examined the mechanisms by which native CRP promotes monocyte-endothelial cell adhesion under static conditions and tested the effect of CRP on adhesion under shear flow. Incubation of HAEC with CRP (>25 microg/ml) upregulated… CONTINUE READING

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