CRNDE, a long non-coding RNA responsive to insulin/IGF signaling, regulates genes involved in central metabolism.

  title={CRNDE, a long non-coding RNA responsive to insulin/IGF signaling, regulates genes involved in central metabolism.},
  author={Blake C. Ellis and Lloyd D. Graham and P. L. Molloy},
  journal={Biochimica et biophysica acta},
  volume={1843 2},
Colorectal neoplasia differentially expressed (CRNDE) is a novel gene that is activated early in colorectal cancer but whose regulation and functions are unknown. CRNDE transcripts are recognized as long non-coding RNAs (lncRNAs), which potentially interact with chromatin-modifying complexes to regulate gene expression via epigenetic changes. Complex alternative splicing results in numerous transcripts from this gene, and we have identified novel transcripts containing a highly-conserved… CONTINUE READING
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