CRM1-mediated nuclear export determines the cytoplasmic localization of the antiapoptotic protein Survivin.

@article{Rodrguez2002CRM1mediatedNE,
  title={CRM1-mediated nuclear export determines the cytoplasmic localization of the antiapoptotic protein Survivin.},
  author={Jos{\'e} A. Rodr{\'i}guez and Simone W. Span and Carlos Gil Ferreira and Frank A. E. Kruyt and Guiseppe Giaccone},
  journal={Experimental cell research},
  year={2002},
  volume={275 1},
  pages={44-53}
}
Survivin is a member of the inhibitor of apoptosis (IAP) family of negative regulators of programmed cell death that is frequently overexpressed in human tumors. Survivin is not only involved in the regulation of apoptosis, but is also known to play a role in the control of cell cycle progression at the G2/M phase. Survivin is a predominantly cytoplasmic protein expressed in a cell cycle-dependent manner, but the mechanism(s) that determine its nuclear-cytoplasmic localization have not been… CONTINUE READING