CRM1- and Ran-independent nuclear export of β-catenin

  title={CRM1- and Ran-independent nuclear export of β-catenin},
  author={Nicola Wiechens and François Fagotto},
  journal={Current Biology},
Background: Activation of the Wnt pathway induces -catenin to localize Address: Max-Planck-Institute for Developmental Biology, Department of Cell Biology, Tübingen inside the nucleus, where it interacts with transcription factors such as D-72076, Germany. TCF/LEF-1. Regulation of the pathway occurs through a -catenin– degrading complex based on Axin and the tumor suppressor APC. We have Correspondence: François Fagotto previously found that -catenin import occurs independently of nuclear… CONTINUE READING