CRKL regulates alternative splicing of cancer-related genes in cervical cancer samples and HeLa cell

@inproceedings{Song2019CRKLRA,
  title={CRKL regulates alternative splicing of cancer-related genes in cervical cancer samples and HeLa cell},
  author={Qingling Song and Fengtao Yi and Yuhong Zhang and Daniel K. Jun Li and Yaxun Wei and Han Wu Yu and Yuan Zhang},
  booktitle={BMC Cancer},
  year={2019}
}
BackgroundAberrant spliced isoforms are specifically associated with cancer progression and metastasis. The cytoplasmic adaptor CRKL (v-crk avian sarcoma virus CT10 oncogene homolog-like) is a CRK like proto-oncogene, which encodes a SH2 and SH3 (src homology) domain-containing adaptor protein. CRKL is tightly linked to leukemia via its binding partners BCR-ABL and TEL-ABL, upregulated in multiple types of human cancers, and induce cancer cell proliferation and invasion. However, it remains… CONTINUE READING
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