CRK protein binds to two guanine nucleotide-releasing proteins for the Ras family and modulates nerve growth factor-induced activation of Ras in PC12 cells.

@article{Matsuda1994CRKPB,
  title={CRK protein binds to two guanine nucleotide-releasing proteins for the Ras family and modulates nerve growth factor-induced activation of Ras in PC12 cells.},
  author={Michiyuki Matsuda and Yukihiro Hashimoto and Koji Muroya and Hiroshi Hasegawa and Tadao Kurata and Shinya Tanaka and Susumu Nakamura and Seisuke Hattori},
  journal={Molecular and cellular biology},
  year={1994},
  volume={14 8},
  pages={
          5495-500
        }
}
It has been reported that growth factors activate Ras through a complex of an adaptor type SH2-containing molecule, Grb2, and a Ras guanine nucleotide-releasing protein (GNRP), mSos. We report on the involvement of another adaptor molecule, CRK, in the activation of Ras. Overexpression of wild-type CRK proteins CRK-I and CRK-II enhanced the nerve growth factor (NGF)-induced activation of Ras in PC12 cells, although the basal level of GTP-bound active Ras was not altered. In contrast, mutants… CONTINUE READING
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