CRISPRs provide broad and robust protection to oral microbial flora of gingival health against bacteriophage challenge

Abstract

Clustered regularly interspaced short palindromic repeats (CRISPR), which are widely present in prokaryotic genomes (Grissa et al., 2007), belong to a family of DNA sequences characterized as short direct repeats (DR) separated by spacers (Jansen et al., 2002). CRISPR and CRISPR-associated (cas) genes are involved in resistance against exogenous sequences… (More)
DOI: 10.1007/s13238-015-0182-0

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