CRISPR screen identifies the NCOR/HDAC3 complex as a major suppressor of differentiation in rhabdomyosarcoma.

@article{Phelps2016CRISPRSI,
  title={CRISPR screen identifies the NCOR/HDAC3 complex as a major suppressor of differentiation in rhabdomyosarcoma.},
  author={Michael P. Phelps and Jenna N Bailey and Terra S. Vleeshouwer-Neumann and Eleanor Y Chen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2016},
  volume={113 52},
  pages={15090-15095}
}
Dysregulated gene expression resulting from abnormal epigenetic alterations including histone acetylation and deacetylation has been demonstrated to play an important role in driving tumor growth and progression. However, the mechanisms by which specific histone deacetylases (HDACs) regulate differentiation in solid tumors remains unclear. Using pediatric rhabdomyosarcoma (RMS) as a paradigm to elucidate the mechanism blocking differentiation in solid tumors, we identified HDAC3 as a major… CONTINUE READING
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