CRISPR provides acquired resistance against viruses in prokaryotes.

@article{Barrangou2007CRISPRPA,
  title={CRISPR provides acquired resistance against viruses in prokaryotes.},
  author={Rodolphe Barrangou and Christophe Fremaux and H{\'e}l{\`e}ne Deveau and Melissa N. Richards and Patrick Boyaval and Sylvain Moineau and Dennis A. Romero and Philippe Horvath},
  journal={Science},
  year={2007},
  volume={315 5819},
  pages={
          1709-12
        }
}
  • Rodolphe Barrangou, Christophe Fremaux, +5 authors Philippe Horvath
  • Published in Science 2007
  • Biology, Medicine
  • Clustered regularly interspaced short palindromic repeats (CRISPR) are a distinctive feature of the genomes of most Bacteria and Archaea and are thought to be involved in resistance to bacteriophages. We found that, after viral challenge, bacteria integrated new spacers derived from phage genomic sequences. Removal or addition of particular spacers modified the phage-resistance phenotype of the cell. Thus, CRISPR, together with associated cas genes, provided resistance against phages, and… CONTINUE READING

    Create an AI-powered research feed to stay up to date with new papers like this posted to ArXiv

    Topics from this paper.

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 2,169 CITATIONS, ESTIMATED 81% COVERAGE

    Cas9 Cleavage of Viral Genomes Primes the Acquisition of New Immunological Memories.

    VIEW 14 EXCERPTS
    CITES BACKGROUND, METHODS & RESULTS
    HIGHLY INFLUENCED

    Diversity of CRISPR/Cas system in Clostridium perfringens

    VIEW 15 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    Manipulation of spermatogonial stem cells in livestock species

    VIEW 17 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    Gene Editing: A New Tool for Viral Disease.

    VIEW 18 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    Metagenomic Analysis of CRISPR-Mediated Host-Virus Interactions in Microbial Communities

    VIEW 25 EXCERPTS
    CITES BACKGROUND & METHODS
    HIGHLY INFLUENCED

    FILTER CITATIONS BY YEAR

    2007
    2020

    CITATION STATISTICS

    • 170 Highly Influenced Citations

    • Averaged 301 Citations per year from 2017 through 2019