CRISPR-mediated adaptive immune systems in bacteria and archaea.

@article{Sorek2013CRISPRmediatedAI,
  title={CRISPR-mediated adaptive immune systems in bacteria and archaea.},
  author={Rotem Sorek and C. Martin Lawrence and Blake Wiedenheft},
  journal={Annual review of biochemistry},
  year={2013},
  volume={82},
  pages={237-66}
}
Effective clearance of an infection requires that the immune system rapidly detects and neutralizes invading parasites while strictly avoiding self-antigens that would result in autoimmunity. The cellular machinery and complex signaling pathways that coordinate an effective immune response have generally been considered properties of the eukaryotic immune system. However, a surprisingly sophisticated adaptive immune system that relies on small RNAs for sequence-specific targeting of foreign… CONTINUE READING
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