CRISPR library designer (CLD): software for multispecies design of single guide RNA libraries

@inproceedings{Heigwer2016CRISPRLD,
  title={CRISPR library designer (CLD): software for multispecies design of single guide RNA libraries},
  author={Florian Heigwer and Tianzuo Zhan and Marco Breinig and Jan Winter and Dirk Br{\"u}gemann and Svenja Leible and Michael Boutros},
  booktitle={Genome Biology},
  year={2016}
}
Genetic screens using CRISPR/Cas9 are a powerful method for the functional analysis of genomes. Here we describe CRISPR library designer (CLD), an integrated bioinformatics application for the design of custom single guide RNA (sgRNA) libraries for all organisms with annotated genomes. CLD is suitable for the design of libraries using modified CRISPR… CONTINUE READING

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