CRISPR gene therapy shows promise against blood diseases.

@article{Ledford2020CRISPRGT,
  title={CRISPR gene therapy shows promise against blood diseases.},
  author={Heidi Ledford},
  journal={Nature},
  year={2020}
}
CRISPR enriches for cells with mutations in a p53-related interactome, and this can be inhibited
TLDR
It is shown that cells deficient in p53, as well as in genes of a core CRISPR-p53 tumor suppressor interactome, are enriched in a cell population whenCRISPR is applied, and that transient p53 inhibition suppresses the enrichment of cells with these mutations.
CRISPR/Cas9-Induced DNA Damage Enriches for Mutations in a p53-Linked Interactome: Implications for CRISPR-Based Therapies
TLDR
It is shown thatCRISPR/Cas9-induced double-stranded DNA breaks enrich for cells deficient in p53 and in genes of a core CRISPR–p53 tumor suppressor interactome, which can be suppressed by transient inhibition of p53.

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