CRISPR-engineered T cells in patients with refractory cancer

@article{Stadtmauer2020CRISPRengineeredTC,
  title={CRISPR-engineered T cells in patients with refractory cancer},
  author={Edward A Stadtmauer and Joseph A. Fraietta and Megan M. Davis and Adam D. Cohen and Kristy Weber and Eric Lancaster and Patricia A. Mangan and Irina Kulikovskaya and Minnal Gupta and Fang Chen and Lifeng Tian and Vanessa E. Gonzalez and Jun Xu and In-Young Jung and Jan Joseph Melenhorst and Gabriela Plesa and Joanne Shea and Tina Matlawski and Amanda Cervini and Avery L Gaymon and Stephanie Desjardins and Anne Lamontagne and January Salas-Mckee and Andrew D. Fesnak and Donald L. Siegel and Bruce L. Levine and Julie K. Jadlowsky and Regina M Young and Anne Chew and Wei-Ting Hwang and Elizabeth O. Hexner and Beatriz M Carreno and Christopher L. Nobles and Frederic D. Bushman and Kevin R. Parker and Yanyan Qi and A. Satpathy and Howard Y. Chang and Yangbing Zhao and Simon F. Lacey and Carl H. June},
  journal={Science},
  year={2020},
  volume={367}
}
CRISPR takes first steps in humans CRISPR-Cas9 is a revolutionary gene-editing technology that offers the potential to treat diseases such as cancer, but the effects of CRISPR in patients are currently unknown. Stadtmauer et al. report a phase 1 clinical trial to assess the safety and feasibility of CRISPR-Cas9 gene editing in three patients with advanced cancer (see the Perspective by Hamilton and Doudna). They removed immune cells called T lymphocytes from patients and used CRISPR-Cas9 to… 
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In defining its superior use, the novel applications of the CRISPR genome editing tool in discovering, sorting, and prioritizing targets for subsequent interventions, and passing different hurdles of cancer treatment such as epigenetic alterations and drug resistance are reviewed.
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The clinical impact of ACT for cancer can be expanded by implementing specific genetic modifications that enhance the potency, safety, and scalability of cellular products, and here a detailed description of such genetic modifications is provided.
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