CRISPR-Cas9 mediated gene knockout in primary human airway epithelial cells reveals a pro-inflammatory role for MUC18


Targeted knockout of genes in primary human cells using CRISPR–Cas9-mediated genome-editing represents a powerful approach to study gene function and to discern molecular mechanisms underlying complex human diseases. We used lentiviral delivery of CRISPR–Cas9 machinery and conditional reprogramming culture methods to knockout the MUC18 gene in human primary… (More)
DOI: 10.1038/gt.2015.53


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Citations per Year

Citation Velocity: 39

Averaging 39 citations per year over the last 2 years.

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