CRISPR-Cas9-based photoactivatable transcription system.

  title={CRISPR-Cas9-based photoactivatable transcription system.},
  author={Yuta Nihongaki and Shun Yamamoto and Fuun Kawano and Hideyuki Suzuki and Moritoshi Sato},
  journal={Chemistry & biology},
  volume={22 2},
Targeted endogenous gene activation is necessary for understanding complex gene networks and has great potential in medical and industrial applications. The CRISPR-Cas system offers simple and powerful tools for this purpose. However, these CRISPR-Cas-based tools for activating user-defined genes are unable to offer precise temporal control of gene expression, despite the fact that many biological phenomena are regulated by highly dynamic patterns of gene expression. Here we created a light… CONTINUE READING

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