CRISPR-Cas9-Mediated Single-Gene and Gene Family Disruption in Trypanosoma cruzi

  title={CRISPR-Cas9-Mediated Single-Gene and Gene Family Disruption in Trypanosoma cruzi},
  author={Duo Peng and Samarchith P. Kurup and Phil Y. Yao and Todd Minning and Rick L. Tarleton},
UNLABELLED Trypanosoma cruzi is a protozoan parasite of humans and animals, affecting 10 to 20 million people and innumerable animals, primarily in the Americas. Despite being the largest cause of infection-induced heart disease worldwide, even among the neglected tropical diseases (NTDs) T. cruzi is considered one of the least well understood and understudied. The genetic complexity of T. cruzi as well as the limited set of efficient techniques for genome engineering contribute significantly… CONTINUE READING
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