CRISPR-Cas immunity in prokaryotes

@article{Marraffini2015CRISPRCasII,
  title={CRISPR-Cas immunity in prokaryotes},
  author={L. Marraffini},
  journal={Nature},
  year={2015},
  volume={526},
  pages={55-61}
}
Prokaryotic organisms are threatened by a large array of viruses and have developed numerous defence strategies. Among these, only clustered, regularly interspaced short palindromic repeat (CRISPR)-Cas systems provide adaptive immunity against foreign elements. Upon viral injection, a small sequence of the viral genome, known as a spacer, is integrated into the CRISPR locus to immunize the host cell. Spacers are transcribed into small RNA guides that direct the cleavage of the viral DNA by Cas… Expand
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Adaptation in CRISPR-Cas Systems.
Antiviral Goes Viral: Harnessing CRISPR/Cas9 to Combat Viruses in Humans.
On the Origin of CRISPR-Cas Technology: From Prokaryotes to Mammals.
How bacteria control the CRISPR-Cas arsenal.
Structural basis of CRISPR-Cas Type III prokaryotic defence systems.
Sensing danger
  • L. Marraffini
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 2016
Engineering virus resistance via CRISPR-Cas systems.
Structural insights into the inactivation of CRISPR-Cas systems by diverse anti-CRISPR proteins
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