CRISPR-Cas immunity in prokaryotes

@article{Marraffini2015CRISPRCasII,
  title={CRISPR-Cas immunity in prokaryotes},
  author={L. Marraffini},
  journal={Nature},
  year={2015},
  volume={526},
  pages={55-61}
}
Prokaryotic organisms are threatened by a large array of viruses and have developed numerous defence strategies. Among these, only clustered, regularly interspaced short palindromic repeat (CRISPR)-Cas systems provide adaptive immunity against foreign elements. Upon viral injection, a small sequence of the viral genome, known as a spacer, is integrated into the CRISPR locus to immunize the host cell. Spacers are transcribed into small RNA guides that direct the cleavage of the viral DNA by Cas… Expand
Harnessing the Prokaryotic Adaptive Immune System as a Eukaryotic Antiviral Defense.
Adaptation in CRISPR-Cas Systems.
Antiviral Goes Viral: Harnessing CRISPR/Cas9 to Combat Viruses in Humans.
On the Origin of CRISPR-Cas Technology: From Prokaryotes to Mammals.
The CRISPR-Cas9 system in Neisseria spp.
  • Y. Zhang
  • Biology, Medicine
  • Pathogens and disease
  • 2017
How bacteria control the CRISPR-Cas arsenal.
Structural basis of CRISPR-Cas Type III prokaryotic defence systems.
Sensing danger
  • L. Marraffini
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 2016
Engineering virus resistance via CRISPR-Cas systems.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 151 REFERENCES
...
1
2
3
4
5
...