CRISPR-Cas immunity in prokaryotes

@article{Marraffini2015CRISPRCasII,
  title={CRISPR-Cas immunity in prokaryotes},
  author={Luciano A. Marraffini},
  journal={Nature},
  year={2015},
  volume={526},
  pages={55-61}
}
Prokaryotic organisms are threatened by a large array of viruses and have developed numerous defence strategies. Among these, only clustered, regularly interspaced short palindromic repeat (CRISPR)-Cas systems provide adaptive immunity against foreign elements. Upon viral injection, a small sequence of the viral genome, known as a spacer, is integrated into the CRISPR locus to immunize the host cell. Spacers are transcribed into small RNA guides that direct the cleavage of the viral DNA by Cas… 
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