CRISPR-Cas encoding of a digital movie into the genomes of a population of living bacteria

@inproceedings{Shipman2017CRISPRCasEO,
  title={CRISPR-Cas encoding of a digital movie into the genomes of a population of living bacteria},
  author={Seth L. Shipman and Jeff Nivala and Jeffrey D Macklis and George M. Church},
  booktitle={Nature},
  year={2017}
}
DNA is an excellent medium for archiving data. Recent efforts have illustrated the potential for information storage in DNA using synthesized oligonucleotides assembled in vitro. A relatively unexplored avenue of information storage in DNA is the ability to write information into the genome of a living cell by the addition of nucleotides over time. Using the Cas1–Cas2 integrase, the CRISPR–Cas microbial immune system stores the nucleotide content of invading viruses to confer adaptive immunity… CONTINUE READING