CRISPR-Cas and restriction-modification systems are compatible and increase phage resistance.

@article{Dupuis2013CRISPRCasAR,
  title={CRISPR-Cas and restriction-modification systems are compatible and increase phage resistance.},
  author={Marie-{\`E}ve Dupuis and Manuela Villion and Alfonso H. Magad{\'a}n and Sylvain Moineau},
  journal={Nature communications},
  year={2013},
  volume={4},
  pages={2087}
}
Bacteria have developed a set of barriers to protect themselves against invaders such as phage and plasmid nucleic acids. Different prokaryotic defence systems exist and at least two of them directly target the incoming DNA: restriction-modification (R-M) and CRISPR-Cas systems. On their own, they are imperfect barriers to invasion by foreign DNA. Here, we show that R-M and CRISPR-Cas systems are compatible and act together to increase the overall phage resistance of a bacterial cell by… CONTINUE READING
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