Corpus ID: 4074946

CRISPR-Cas : To Take Up DNA

  title={CRISPR-Cas : To Take Up DNA},
  author={D. Weinberger and M. Gilmore},
Historically landmark experiments showed that capsule switching is critical for Streptococcus pneumonia survival. Further studies demonstrated that capsule ‘transformation’ occurs via DNA uptake. In this issue of Cell Host and Microbe, Bikard et al. (2012) show that CRISPR-Cas systems inhibit DNA uptake, selecting for the outgrowth of CRISPR-defective pneumococci. To take up DNA or not to take up DNA – that is the question. Each microbe must balance the need to acquire new beneficial traits by… Expand

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