CRISPR — a widespread system that provides acquired resistance against phages in bacteria and archaea

@article{Sorek2008CRISPRA,
  title={CRISPR — a widespread system that provides acquired resistance against phages in bacteria and archaea},
  author={R. Sorek and V. Kunin and P. Hugenholtz},
  journal={Nature Reviews Microbiology},
  year={2008},
  volume={6},
  pages={181-186}
}
Arrays of clustered, regularly interspaced short palindromic repeats (CRISPRs) are widespread in the genomes of many bacteria and almost all archaea. These arrays are composed of direct repeats that are separated by similarly sized non-repetitive spacers. CRISPR arrays, together with a group of associated proteins, confer resistance to phages, possibly by an RNA-interference-like mechanism. This Progress discusses the structure and function of this newly recognized antiviral mechanism. 
CRISPR-Cas: an adaptive immunity system in prokaryotes
CRISPR/Cas system and its role in phage-bacteria interactions.
CRISPR/Cas systems in archaea
Characterizing Metal-Dependent Nucleases of CRISPR-Cas Prokaryotic Adaptive Immunity Systems.
RNA in defense: CRISPRs protect prokaryotes against mobile genetic elements.
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