CRISPR — a widespread system that provides acquired resistance against phages in bacteria and archaea

  title={CRISPR — a widespread system that provides acquired resistance against phages in bacteria and archaea},
  author={R. Sorek and V. Kunin and P. Hugenholtz},
  journal={Nature Reviews Microbiology},
  • R. Sorek, V. Kunin, P. Hugenholtz
  • Published 2008
  • Biology, Medicine
  • Nature Reviews Microbiology
  • Arrays of clustered, regularly interspaced short palindromic repeats (CRISPRs) are widespread in the genomes of many bacteria and almost all archaea. These arrays are composed of direct repeats that are separated by similarly sized non-repetitive spacers. CRISPR arrays, together with a group of associated proteins, confer resistance to phages, possibly by an RNA-interference-like mechanism. This Progress discusses the structure and function of this newly recognized antiviral mechanism. 
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