CRISPR–Cas systems: beyond adaptive immunity

@article{Westra2014CRISPRCasSB,
  title={CRISPR–Cas systems: beyond adaptive immunity},
  author={Edze R. Westra and Angus Buckling and Peter C. Fineran},
  journal={Nature Reviews Microbiology},
  year={2014},
  volume={12},
  pages={317-326}
}
  • Edze R. Westra, Angus Buckling, Peter C. Fineran
  • Published 2014
  • Medicine, Biology
  • Nature Reviews Microbiology
  • The discovery of CRISPR–Cas (clustered, regularly interspaced short palindromic repeats–CRISPR-associated proteins) adaptive immune systems in prokaryotes has been one of the most exciting advances in microbiology in the past decade. Their role in host protection against mobile genetic elements is now well established, but there is mounting evidence that these systems modulate other processes, such as the genetic regulation of group behaviour and virulence, DNA repair and genome evolution. In… CONTINUE READING

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    Evolution and classification of the CRISPR–Cas systems