CRISPR/Cas9 mediated knockout of rb1 and rbl1 leads to rapid and penetrant retinoblastoma development in Xenopus tropicalis

  title={CRISPR/Cas9 mediated knockout of rb1 and rbl1 leads to rapid and penetrant retinoblastoma development in Xenopus tropicalis},
  author={Thomas Naert and Robin Colpaert and Tom Van Nieuwenhuysen and Dionysia Dimitrakopoulou and Jannick Leoen and Jurgen Haustraete and Annekatrien Boel and Wouter Steyaert and Trees Lepez and Dieter Deforce and Andy Willaert and David Creytens and Kris Vleminckx},
  booktitle={Scientific reports},
Retinoblastoma is a pediatric eye tumor in which bi-allelic inactivation of the Retinoblastoma 1 (RB1) gene is the initiating genetic lesion. Although recently curative rates of retinoblastoma have increased, there are at this time no molecular targeted therapies available. This is, in part, due to the lack of highly penetrant and rapid retinoblastoma animal models that facilitate rapid identification of targets that allow therapeutic intervention. Different mouse models are available, all… CONTINUE READING
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