CRISPR/Cas9-mediated MSTN disruption and heritable mutagenesis in goats causes increased body mass.

@article{Wang2018CRISPRCas9mediatedMD,
  title={CRISPR/Cas9-mediated MSTN disruption and heritable mutagenesis in goats causes increased body mass.},
  author={Xiaoyu Wang and Y Niu and Jia-qi Zhou and Hesun Zhu and Baohua Ma and Honghao Yu and Hailong Yan and Jinlian Hua and Xuan Huang and Lei Qu and Yin Chen},
  journal={Animal genetics},
  year={2018},
  volume={49 1},
  pages={43-51}
}
Genetic engineering in livestock has been greatly enhanced through the use of artificial programmed nucleases such as the recently emerged clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated 9 (Cas9) system. We recently reported our successful application of the CRISPR/Cas9 system to engineer the goat genome through micro-injection of Cas9 mRNA and sgRNAs targeting MSTN and FGF5 in goat embryos. The phenotypes induced by edited loss-of-function mutations of MSTN… CONTINUE READING
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