CRISPR/Cas, the immune system of bacteria and archaea.

@article{Horvath2010CRISPRCasTI,
  title={CRISPR/Cas, the immune system of bacteria and archaea.},
  author={Philippe Horvath and Rodolphe Barrangou},
  journal={Science},
  year={2010},
  volume={327 5962},
  pages={
          167-70
        }
}
Microbes rely on diverse defense mechanisms that allow them to withstand viral predation and exposure to invading nucleic acid. In many Bacteria and most Archaea, clustered regularly interspaced short palindromic repeats (CRISPR) form peculiar genetic loci, which provide acquired immunity against viruses and plasmids by targeting nucleic acid in a sequence-specific manner. These hypervariable loci take up genetic material from invasive elements and build up inheritable DNA-encoded immunity over… CONTINUE READING

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