CRISPR/Cas, the Immune System of Bacteria and Archaea

  title={CRISPR/Cas, the Immune System of Bacteria and Archaea},
  author={P. Horvath and R. Barrangou},
  pages={167 - 170}
  • P. Horvath, R. Barrangou
  • Published 2010
  • Medicine, Biology
  • Science
  • CRISPR Defenses Prokaryotes can be infected by parasites and pathogens and, like eukaryotes, have evolved systems to protect themselves. Horvath and Barrangou (p. 167) review a recently discovered prokaryotic “immune system” characterized by CRISPR—clustered regularly interspaced short palindromic repeats—found in most archaeal and many bacterial species. CRISPR loci harbor short sequences captured from viruses and invasive genetic elements. These sequences are transcribed, and the RNA is… CONTINUE READING
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