CRISPR/Cas, the Immune System of Bacteria and Archaea

@article{Horvath2010CRISPRCasTI,
  title={CRISPR/Cas, the Immune System of Bacteria and Archaea},
  author={P. Horvath and R. Barrangou},
  journal={Science},
  year={2010},
  volume={327},
  pages={167 - 170}
}
CRISPR Defenses Prokaryotes can be infected by parasites and pathogens and, like eukaryotes, have evolved systems to protect themselves. Horvath and Barrangou (p. 167) review a recently discovered prokaryotic “immune system” characterized by CRISPR—clustered regularly interspaced short palindromic repeats—found in most archaeal and many bacterial species. CRISPR loci harbor short sequences captured from viruses and invasive genetic elements. These sequences are transcribed, and the RNA is… Expand
1,747 Citations
CRISPRs in the Human Microbiome
CRISPR‐Cas systems and RNA‐guided interference
  • R. Barrangou
  • Biology, Medicine
  • Wiley interdisciplinary reviews. RNA
  • 2013
  • 144
Suppressing the CRISPR/Cas adaptive immune system in bacterial infections
  • 9
Genomic impact of CRISPR immunization against bacteriophages.
  • 41
  • PDF
An Archaeal Immune System Can Detect Multiple Protospacer Adjacent Motifs (PAMs) to Target Invader DNA*
  • 115
  • PDF
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 67 REFERENCES
CRISPR-based adaptive and heritable immunity in prokaryotes.
  • 436
Small CRISPR RNAs Guide Antiviral Defense in Prokaryotes
  • 1,731
  • PDF
RNA-Guided RNA Cleavage by a CRISPR RNA-Cas Protein Complex
  • 818
  • PDF
Phage response to CRISPR-encoded resistance in Streptococcus thermophilus.
  • 995
  • PDF
...
1
2
3
4
5
...