CRIF1 is essential for the synthesis and insertion of oxidative phosphorylation polypeptides in the mammalian mitochondrial membrane.

@article{Kim2012CRIF1IE,
  title={CRIF1 is essential for the synthesis and insertion of oxidative phosphorylation polypeptides in the mammalian mitochondrial membrane.},
  author={Soung Jung Kim and Min-chul Kwon and Min Jeong Ryu and Hyo Kyun Chung and Surendar Tadi and Yong Kyung Kim and Jin-man Kim and Sang Hee Lee and Ji Hoon Park and Gi Ryang Kweon and Seung-wook Ryu and Young Suk Jo and Chul-Ho Lee and Hideyuki Hatakeyama and Yu-ichi Goto and Y N Yim and Jongkyeong Chung and Young-Yun Kong and Minho Shong},
  journal={Cell metabolism},
  year={2012},
  volume={16 2},
  pages={274-83}
}
Although substantial progress has been made in understanding the mechanisms underlying the expression of mtDNA-encoded polypeptides, the regulatory factors involved in mitoribosome-mediated synthesis and simultaneous insertion of mitochondrial oxidative phosphorylation (OXPHOS) polypeptides into the inner membrane of mitochondria are still unclear. In the present study, disruption of the mouse Crif1 gene, which encodes a mitochondrial protein, resulted in a profound deficiency in OXPHOS caused… CONTINUE READING