CRHR2/Ucn2 signaling is a novel regulator of miR-7/YY1/Fas circuitry contributing to reversal of colorectal cancer cell resistance to Fas-mediated apoptosis.

Abstract

Colorectal cancer (CRC) responds poorly to immuno-mediated cytotoxicity. Underexpression of corticotropin-releasing-hormone-receptor-2 (CRHR2) in CRC, promotes tumor survival, growth and Epithelial to Mesenchymal Transition (EMT), in vitro and in vivo. We explored the role of CRHR2 downregulation in CRC cell resistance to Fas/FasL-mediated apoptosis and the… (More)
DOI: 10.1002/ijc.31064

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@article{Pothoulakis2018CRHR2Ucn2SI, title={CRHR2/Ucn2 signaling is a novel regulator of miR-7/YY1/Fas circuitry contributing to reversal of colorectal cancer cell resistance to Fas-mediated apoptosis.}, author={Charalabos Pothoulakis and Monica Torre-Rojas and Marco A. Dur{\'a}n-Padilla and Jonathan Gevorkian and Odysseas L Zoras and Emmanuel Chrysos and George E. Chalkiadakis and Stavroula Baritaki}, journal={International journal of cancer}, year={2018}, volume={142 2}, pages={334-346} }